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MSA 70% (Methane Sulfonic Acid)

Discover the Product range Sulfonyls.
CAS 75-75-2
Product overview

MSA 70% (Methane Sulfonic Acid) is an organic acid with the chemical formula CH3SO3H. It is a colorless, viscous liquid that is soluble in water and polar organic solvents. MSA is a strong acid, meaning that it readily donates protons (H+) to other molecules in solution. It is commonly used in organic synthesis and as a catalyst in various chemical reactions. Thanks to its versatility, MSA 70% is a viable substitute for organic and inorganic strong acids in a variety of applications. 

Geographic availability
  • Worldwide

Chemical name: Methane Sulfonic Acid
Common name: MSA 70%

What are the properties of Methane sulfonic acid (MSA)?

Chemical structure of MSA

The chemical structure of Methanesulfonic acid (MSA) consists of a central carbon atom (C) bonded to three hydrogen atoms (H). One of the hydrogen atoms is also bonded to a sulfur atom (S), and the sulfur atom is further bonded to three oxygen atoms (O). These oxygen atoms are also bonded to a hydrogen atom each. This arrangement gives MSA its distinct properties as a strong organic acid.


Physical properties of MSA:
  • Colorless or light yellow liquid
  • Odorless or with a slight sulfuric odor
  • Highly soluble in water forming a homogeneous solution and is miscible with most polar organic solvents.
  • Relatively high density (~1.48 g/mL at room temperature)
  • High boiling point (~167°C or 332°F

What are the benefits of Methane sulfonic acid (MSA)?

Methane sulfonic acid (MSA) is a versatile and valuable chemical compound that offers a range of benefits across various industries. Its unique properties make it a preferred choice for numerous applications.


  • Strong Acidic Properties: MSA exhibits high acidity, allowing it to efficiently catalyze chemical reactions. Its potent acidic properties make it a valuable catalyst in numerous industrial processes, promoting faster and more selective reactions.
  • Non-Volatile and Non-Oxidizing: Unlike volatile acids, MSA is non-volatile, ensuring safer handling and reduced risks of harmful vapors. Additionally, its non-oxidizing nature minimizes the risk of corrosion or degradation of materials, making it compatible with a wide range of substances.
  • Versatile Solvent: MSA possesses excellent solvency power, making it an effective solvent for both polar and non-polar compounds. It can dissolve various organic and inorganic substances, facilitating processes such as extraction, purification, and synthesis in industries such as pharmaceuticals, electroplating, and organic chemistry.
  • Stability and Long Shelf Life: Methane sulfonic acid is known for its exceptional stability. It can be stored for extended periods without significant decomposition or loss of potency. This stability ensures a longer shelf life compared to many other corrosive acids, allowing for better inventory management and reduced wastage.
  • Environmentally Friendly: In terms of environmental impact, MSA stands out positively. It is biodegradable, meaning it can be broken down by natural processes over time. MSA provides environmental advantages through easy recyclability and the generation of "green" effluent. Its recyclable nature allows for efficient reuse and waste reduction. Furthermore, MSA is considered as a "green" effluent as it produces environmentally friendly effluent, minimizing harm to ecosystems.

What are the applications of Methane sulfonic acid (MSA)?

Methane sulfonic Acid (MSA) has a wide range of industrial applications due to its strong acid properties, high solubility in water, and chemical stability. Some of the main applications of MSA include:

  • Electroplating: MSA is used as an electrolyte in electroplating processes, such as nickel plating, copper plating, and tin plating. It acts as a buffer to maintain the pH of the electrolyte solution and helps to ensure a uniform coating on the metal substrate.
  • Industrial Cleaning (Equipment & Hard Surface Cleaning): Methane sulfonic acid (MSA) is widely employed in industrial cleaning applications due to its effective and versatile properties. It acts as a strong acid cleaner, capable of removing various types of contaminants and residues from surfaces and equipment, maintaining the formed salts in solution throughout the cleaning process thanks to their high solubility. MSA's reactivity and properties make it suitable, efficient, and more sustainable agent for removing mineral deposits, rust, scale, and organic substances.
  • Oilfield (Well stimulation): MSA is utilized in the oilfield industry for acidizing treatments, enhancing production by dissolving mineral deposits and improving reservoir permeability. It acts as a catalyst, aiding in the breakdown of complex hydrocarbons and increasing oil recovery efficiency. MSA offers benefits of reduced corrosion and biodegradability, minimizing equipment corrosion and extending lifespan on one side and reducing maintenance costs on the other. Additionally, MSA's biodegradable properties contribute to environmentally friendly oilfield practices.
  • Chemical Industry (Esterification): MSA is a vital catalyst in the chemical industry, particularly for esterification processes. Its strong acidic properties enable efficient and selective ester formation from carboxylic acids and alcohols. MSA's versatility and compatibility with different substrates make it an essential component in the synthesis of pharmaceuticals, fragrances, flavors, and specialty chemicals. Higher selectivity is obtained with MSA than with other strong acids such as nitric or sulfuric acids thanks to its non-oxidizing property, preventing by product formation and product coloration.
  • Biodiesel (Esterification Catalyst): Its application in biodiesel value chain involves key stages from esterification catalyst to lower free fatty acid content before transesterification to neutralization to improve quality of glycerol and ester. MSA-LC in biodiesell production offers dual benefits of reducing corrosion and utilizing cost-effective feedstocks. As a catalyst, MSA-LC minimizes  stainless steel equipment corrosion while enabling efficient conversion processes. It also allows for the use of cheaper feedstocks like agricultural residues, used cooking oil, wastes cooking oils, enhancing the economic viability of biodiesel production. MSA plays a vital role in making biofuels more sustainable and economically feasible.
  • Pharmaceuticals (API synthesis, drug formulation, etc.): Methane sulfonic acid (MSA) plays a significant role in various pharmaceutical applications, ranging from active pharmaceutical ingredient (API) synthesis to drug formulation. As a catalyst, MSA facilitates key reactions in API synthesis, such as esterification, acylation, and sulfonation. Its effectiveness in promoting these reactions allows for the efficient production of pharmaceutical intermediates and final APIs. MSA is also utilized in drug formulation processes, where it aids in solubilizing and stabilizing active compounds. Its compatibility with a wide range of solvents and its mild nature contribute to the development of safe and effective pharmaceutical formulations.



How Methane sulfonic Acid (MSA) is contributing to bring more sustainable solutions?

Methane sulfonic acid (MSA) offers notable environmental benefits across various applications. Here are some key environmental advantages of MSA:


  • Biodegradability: MSA is biodegradable and can be broken down by microorganisms in the environment. This means that it is unlikely to persist in the environment or accumulate in living organisms.
  • Persistence: MSA has a low persistence in the environment and does not accumulate in living organisms. It is rapidly degraded in water, soil, and sediment, which reduces its potential impact on the environment.
  • Toxicity: MSA is not considered to be toxic to aquatic or terrestrial organisms at environmentally relevant concentrations. This means that it is unlikely to cause harm to wildlife or ecosystems.
  • Air Quality Benefits: In certain applications, MSA can offer advantages over other acids in term of volatile organic compounds (VOCs) and hazardous air pollutants (HAPs). By using MSA as a cleaner or catalyst, the production of undesirable products  VOCs and HAPs can be minimized (strong but non-oxidizing acid), leading to improved air quality.
  • Sustainable Synthesis: MSA's catalytic properties enable more sustainable synthesis processes in various industries. Its use as a catalyst can reduce the need for harsher reagents, minimize waste generation, and improve overall process efficiency.
  • Lower Environmental Impact: When compared to certain alternatives, such as mineral acids or strong organic acids, MSA can have a lower environmental impact. Its production typically involves less energy-intensive processes and generates fewer harmful byproducts.

What are the potential for future research and development in MSA applications?

There is potential for future research and development in the applications of Methane sulfonic Acid (MSA) due to its unique properties and versatility in various industries.


In the pharmaceutical industry, MSA has shown promise as a catalyst for organic reactions and as a solvent for drug formulation. Further research could explore the potential of MSA in the development of new drugs and therapeutic agents.

In the field of catalysis, MSA has been shown to be an effective acid catalyst in a range of organic reactions. Future research could focus on optimizing the use of MSA in various catalytic reactions and developing new methods  potential recycling.

Its environmentalally friendly profile makes it the acid of choice for the development of new processes in a variety of domains ranging from oil& gas to mining and metal treatment / recycling.

Additionally, MSA has potential in the development of new materials such as polymers and composites due to its ability to modify the properties of organic compounds. Research in this area could lead to the development of new materials with unique properties and applications.

Finally, there is potential for research in the environmental impact of MSA and the development of more sustainable methods for its production and use. This could include exploring alternatives to traditional methods of MSA production, such as biocatalytic processes or green chemistry approaches.

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