Methane Sulfonic Acid Anhydrous (AMSA or MSAA)

Arkema AMSA (methane sulfonic acid anhydrous - CAS 75-75-2) enjoys wide use in the pharmaceutical industry due to its high acidity and high miscibility in aqueous and most organic media. Its uses include:

• formation of pharmacologically acceptable API salts


• extraction, crystallization and purification of synthetic intermediates


• synthetic raw material


• acid catalyst, particularly for formation and removal of protecting groups


• dehydrating reaction solvent

AMSA is a strong organic acid (pKa-1.92). As such, it is highly corrosive in its acid form.