Sulfonyls
Arkema has the largest sulfonyls range including MSA (methane sulfonic acid - CAS 75-75-2) and MSC (methane sulfonic chloride - CAS 124-63-0). Arkema has been manufactured methane sulfonic acid for more than 40 years, and has developed various grades adapted to customer's applications for MSA (CH3SO3H) based on its high acidity and full biodegradability. MSC (CH3SO2Cl), is a versatile, reactive chemical used in the agrochemical, pharmaceutical, photographic. It is also commonly known as mesyl chloride.
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Methane Sulfonic acid (MSA)
MSA (methane sulfonic acid) has lower color product, and is biodegradable. MSA has no toxic fumes, has low toxicity to aquatic life, contains no phenol and completely miscible in water.
MSA is recognized as an ideal acid for:
- Electroplating - achieving a smooth and uniform metal deposit
- Catalysis - high bronsted acidity affording high productivity, high product quality, and easier handling of waste streams.
- Fine chemicals - for API salt preparation
- Cleaning agent - for rapid descaling and metal rust removal
- Reaction solvent - allowing synthesis in a strongly acidic but non-oxidizing medium
- Neutralizing agent - to obtain soluble salts
Arkema produces various grades of MSA acid tailored for specific applications:
- MSA 70%
- E-Pure® MSA
- MSA LC
- Scaleva® MSA
- AMSA (anhydrous MSA)
Methane Sulfonyl Chloride (MSC) or Mesyl Chloride
Methane Sulfonyl Chloride (MSC) - also known as Mesyl Chloride - is a building block for intermediates and products in fine chemistry, pharmaceuticals, and agrochemicals
- MSC is a reactive acid chloride widely used in synthesis of sulfonamides, sulfonimides, sulfones, and sulfonate esters.
- Arkema offers global distribution of MSC under controlled safe conditions in drums or in bulk.
How Sulfonyls are contributing to bringing more sustainable solutions?
An eco-friendly solution for cleaning water membranes
Scaleva® MSA is the solution for descaling applications including cooling towers, evaporative coolers, hot water boilers, and processing equipment (including water treatment membranes). Readily biodegradable, Scaleva® has an excellent HSE profile compared to other alternatives. Moreover, dilute solutions are safe for discharge to water treatment facilities as Scaleva® contains no phosphorus or nitrogen, two water pollutants that cause eutrophication (dense growth of aquatic plants leading to the death of animal life from lack of oxygen) in rivers, lakes and other bodies of water.
Enabler for biodiesel manufacturing from recycled feedstocks
Arkema offers innovative thiochemical solutions which allow biodiesel manufacturers to produce the highest quality of biodiesel in a safe and cost-effective manner. MSA LC (Low Corrosion) is a strong acid that can be used as an acidulation or neutralization agent, or as a (trans)esterification catalyst that improves yield for biodiesel producers.This allows the use of advantaged feedstocks like waste oils or animal fats, while significantly reducing the corrosivity toward stainless steel materials.
(TIN) electroplating: fewer side reactions and higher performance
E-Pure MSA® replaces most classical acids used in Sn or Sn/Pb electroplating baths, and frees processes from toxic lead and hazardous fluoborates. With E-Pure MSA®, bath can operate with lower metal content and allows for reduced waste, sludge and fewer residues and effluents. E-Pure MSA® also offers the possibility to recycle electrolytes.
Sulfonyls Frequently Asked Questions (FAQ)
Welcome to our FAQ section on sulfonyls. Here, we provide essential information about sulfonyls and their crucial role in various industrial applications. Sulfonyls, characterized by the -SO2- functional group, are used as intermediates in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. We hope this FAQ section answers your questions about sulfonyls and their uses, and helps you better understand their crucial role in the industry. By understanding their importance, we can all contribute to a more effective and innovative use of these chemical compounds in various fields.
Q1: What are sulfonyls?
Sulfonyl derivatives are a class of chemical compounds characterized by the presence of the sulfonyl functional group (-SO2-). This group consists of a sulfur atom double-bonded to two oxygen atoms and is commonly attached to an organic moiety. Sulfonyls exhibit diverse chemical properties and find extensive use in various industries.
Arkema sulfonyls range covers several grades of Methane Sulfonic Acid, first alkane sulfonic acid and Methanesulfonyl chloride.
Q2: How are sulfonyls utilized in industrial applications?
Sulfonyls play a crucial role in numerous industrial processes and applications. They are employed as intermediates in organic synthesis, serving as building blocks for the production of pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, sulfonyls are utilized as reagents in chemical reactions, electrolytes in plating industry and as components in polymer chemistry, materials science and cleaning formulations.
Q3: What are the key characteristics of sulfonyls?
Sulfonyls are known for their exceptional stability and chemical reactivity, making them valuable components in synthetic chemistry.
Methanesulfonic acid displays strong acidity, great solubility in aqueous media and its salts can be soluble in high concentrations versus respective sulfates. Its non-oxidative profile and great thermal stability makes it a great brönsted acid catalyst for a variety of reactions with the advantage of selectivity improvement and better coloration of resulting products.
Methanesulfonic acid is biodegradable and part of natural cycle of organic sulfur. It is often considered as a bio-acid.
Methanesulfonyl chloride is a versatile building block used in pharmaceutical industry as well as in agrochemicals manufacturing, used to introduce the methanesulfonyl moiety on other reactive molecules: ie through reaction with alcohol (forming methanesulfonate), amine ( forming methanesulfonamide), alkynes (forming chlorosulfones) etc.
Methanesulfonylchloride is readily hydrolyzed in the environment, generating Methane sulfonic acid and HCl, and is then biodegraded as methanesulfonic acid.
Q4: How do sulfonyls contribute to the pharmaceutical industry?
Sulfonyls are extensively used in pharmaceutical synthesis, where they serve as essential intermediates in the production of various drugs. Their unique chemical structure enables the creation of complex molecular scaffolds, facilitating the development of novel therapeutic agents with improved efficacy and selectivity.
The salification of amine bearing API is a specific application in which anhydrous methanesulfonic acid is used extensively. It enables the production of high solubility API salts improving its bioavailability in the organism. Its strong acidity but non oxidative profile makes it a good counter ion candidate for a variety of weak and strong bases. It thus compares favorably versus most organic acids (weaker acids) and versus inorganic acids displaying handling issues.
Q5: Are sulfonyls environmentally friendly?
Methanesulfonic acid is greatly appreciated for its environmentally friendly properties, being readily biodegradable with low Chemical Oxygen Demand and not bringing any nitrate or phosphate to the environment (known for their consequences on waterways eutrophication phenomenon).
Methanesulfonic acid is part of natural cycle of organic sulfur and often considered as a bio-acid.
Its thermal stability makes it possible to be recycled in some processes as well.
Q6: Can Arkema provide customized sulfonyls for specific applications?
Yes, Arkema is dedicated to assist customers and partners in their developments and is able to adjust its sulfonyles portfolio to make sure we deliver the required quality to the most stringent markets.
We also innovate by developing MSA Low Corrosion grade (MSA LC) so that our customers can use more economic materials in their installation to store and still benefit from unique methanesulfonic acid performances.
Q7: How do I request further information or inquire about Arkema's sulfonyls?
To learn more about Arkema's sulfonyls or to discuss your specific requirements, please contact our sales team using the provided contact information. We are dedicated to providing personalized assistance and prompt responses to address your inquiries effectively.